Our most recent study conducted by Aspire Allergy & Sinus' very own Dr. Chris Thompson and Dr. Stacy Silvers, with Dr. Mark Adam Shapiro
(ExACT) Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: A 3-year randomized placebo-controlled trial (Read the Study)
(ExACT) Intralymphatic Immunotherapy against grass pollen (Read the Study)
2008 ILIT Study
2012 Cat Study
2015 WHO Review
2016 Study
2017 Study Summary
2018 Study with dust, dog and cat
Hylander Grass Study
Why time interval between injections is essential
2019 cervical intralymphatic immunotherapy study for house dust mite allergic rhinitis
Efficacy of allergen-specific immunotherapy for peanut allergy: a meta-analysis of randomized controlled trials
Peanut Sublingual Immunotherapy Provides Desensitization to Peanut in Toddlers
Other Studies:
Fernandez Rivas Study on Sublingual Therapy
Fleisher Study on Sublingual Immunotherapy for Peanut Allergy
Narisety Sublingual vs Oral Immunotherapy for Food Allergy
World Allergy Position Statement on Sublingual Therapy
Sublingual immunotherapy: current concepts for the U.S. practitioner
JAMA Network-Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review
Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis
Role of Immunotherapy in the Treatment of Asthma
Early sublingual immunotherapy for allergic rhinitis reduces risks for allergic asthma
Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
Article
Safety of sublingual-swallow therapy in children and adults.
Intl Arch Allergy Immunol.
2000 Mar; 121(3):229-34
Article
Review of 8 studies containing 690 patients. No serious reactions.
Grass pollen specific sublingual/swallow immunotherapy in children: open controlled comparison among different treatment protocols.
Allergologia et Immunopathogia
1999. 27(3): 145-51
Article
268 children (age 2-15 years), approximately 96,000 doses of allergy drops
No serious or life-threatening reactions
Adverse events rate: 0.83 per 1000 doses (3% of children in the study)
7 adverse events requiring no treatment (including stomach pain, itchy eyes, nasal congestion)
1 case of hives which required treatment with an antihistamine
Safety of sublingual immunotherapy with monomeric allergoid in adults: multicenter post-marketing surveillance study.
Article
198 patients, 32,800 doses of allergy drops
Adverse event rate was 0.52 per 1000 doses
Most required no treatment
Dose adjustment was needed in 4 patients (2 for stomach pain, 2 for hives)2 patients needed antihistamine (1 for hives, 1 for itchy eyes)
Efficacy of sublingual immunotherapy in asthma and eczema.
Chemical Immunology & Allergy, 2003. 82: 77-88.
Article
344 children (age 5-12 years) undergoing allergy therapy for allergic asthma
No serious reactions
10% had an adverse reaction
Most common side effects were tiredness and/or headache
Most adverse events occurred during initial dose escalation
Wheezing in 2 patients (one was “mild”, the other was “moderate”)
Treatment stopped in 5 patients as a precaution (1 for nasal allergy symptoms, 2 for hives, 2 for wheezing)
Curr Med Res Opin.
Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections.
Article
Seasonal allergens and performance in school
Highlights
- Seasonal pollen allergies affect 1 in 5 school age children
- Allergies have a negative affect on children in school performance
Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
Article
Sublingual immunotherapy: past, present, paradigm for the future? A review of the literature.
Otolayngol Head Neck Surg 2007; 136:S1-20
Article
Review of 36 previous studies - 30 out of 36 studies showed efficacy in reduction of allergy symptoms, decrease in medication use or both. Efficacy shown for both seasonal and perennial allergens
Sublingual immunotherapy or allergic rhinitis: systematic review and meta-analysis.
Allergy 2005; 60: 4-12
Article
Review of 22 previous double-blinded placebo controlled trials (adults and/or children)Significant reduction in symptom and medication scores
Efficacy clearly shown for combined ages and adults alone but not for children alone
Smaller number of studies evaluating children
Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3-18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials.
Annals All Asth Immunol. 97(2): 141-8, 2006 Aug.
Article
10 previous studies of children receiving SLIT were reviewed
Significant improvement in symptom scores and medication scores
Subset analysis showed significant improvement for pollens only and for treatment duration of more than 18 months.Dust mites fell short of significance, but studies with higher doses did show significant improvement.
Sublingual immunotherapy for allergic rhinitis (including hay fever)
Cochrane Review February 2011.
Article
Review of 60 previous studies
Significant improvement in symptom and medication in patients treated with sublingual drops
No serious adverse reactions
Sublingual immunotherapy (tablets, spray, or drops under the tongue) to treat inflammation of the conjunctiva due to allergy.
Cochrane Review July 2011.
Article
Review of 42 previous studies
Sublingual therapy can reduce symptoms of allergic conjunctivitis (itchy/watery eyes)
Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites.
Article
Mar;7(2):118-23. doi: 10.4168/aair.2015.7.2.118. Epub 2014 Oct 30.
Efficacy of sublingual specific immunotherapy in patients with respiratory allergy to Alternaria alternata: a randomized, assessor-blinded, patient-reported outcome, controlled 3-year trial.
Article
There have been a number of studies comparing allergy shots and drops. Some have shown that drops are better at treating nasal allergies, while others have shown that shots are better. Most have shown equal results between the two options. The opinion of Aspire Allergy & Sinus is that allergy shots and allergy drops have roughly the same effectiveness at treating allergies, and that allergy drops are safer than shots (though both are very safe if proper precautions are taken).
Here are a few references of studies comparing shots and drops:
Injective versus sublingual immunotherapy in Alternaria tenuis allergic patients
Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma--a placebo controlled study
Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study
